Basic studies on the laboratory assessment of macrofilaricides using Brugia malayi in the jird, Meriones unguiculatus. 1. Longevity and periodicity of microfilaremia.
Identifieur interne : 00E304 ( Main/Exploration ); précédent : 00E303; suivant : 00E305Basic studies on the laboratory assessment of macrofilaricides using Brugia malayi in the jird, Meriones unguiculatus. 1. Longevity and periodicity of microfilaremia.
Auteurs : R. Maeda [Japon] ; Y. Hayashi ; T. ShibuyaSource :
- The Japanese journal of experimental medicine [ 0021-5031 ] ; 1988.
Descripteurs français
- KwdFr :
- Animaux, Antihelminthiques (usage thérapeutique), Brugia (croissance et développement), Brugia (isolement et purification), Composés de l'arsenic (usage thérapeutique), Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Filarioses (parasitologie), Filarioses (traitement médicamenteux), Gerbillinae (parasitologie), Microfilaria, Mâle, Mébendazole (analogues et dérivés), Mébendazole (usage thérapeutique), Périodicité, Suramine (usage thérapeutique), Évaluation préclinique de médicament ().
- MESH :
- analogues et dérivés : Mébendazole.
- croissance et développement : Brugia.
- isolement et purification : Brugia.
- parasitologie : Filariose lymphatique, Filarioses, Gerbillinae.
- sang : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Antihelminthiques, Composés de l'arsenic, Diéthylcarbamazine, Filaricides, Mébendazole, Suramine.
- Animaux, Femelle, Microfilaria, Mâle, Périodicité, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Anthelmintics (therapeutic use), Arsenicals (therapeutic use), Brugia (growth & development), Brugia (isolation & purification), Diethylcarbamazine (therapeutic use), Drug Evaluation, Preclinical (methods), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Female, Filariasis (drug therapy), Filariasis (parasitology), Filaricides (therapeutic use), Gerbillinae (parasitology), Male, Mebendazole (analogs & derivatives), Mebendazole (therapeutic use), Microfilariae, Periodicity, Suramin (therapeutic use).
- MESH :
- chemical , analogs & derivatives : Mebendazole.
- blood : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- growth & development : Brugia.
- isolation & purification : Brugia.
- methods : Drug Evaluation, Preclinical.
- parasitology : Elephantiasis, Filarial, Filariasis, Gerbillinae.
- chemical , therapeutic use : Anthelmintics, Arsenicals, Diethylcarbamazine, Filaricides, Mebendazole, Suramin.
- Animals, Female, Male, Microfilariae, Periodicity.
Abstract
The longevity and periodicity of microfilaremia were examined in the jird infected with Brugia malayi to be used for assessing the filaricides. Jirds 4 to 6 weeks old were inoculated subcutaneously with 100 to 200 infective larvae of B. malayi. Microfilariae were present in 75 out of 94 jirds observed over 3 years and high microfilaremia, with 10 mf/microliters or higher, developed in 43 out of 75 jirds. Such a high level of microfilaremia was necessary for narrowing the variation of microfilaria counts among the blood samples. The microfilaria negative jirds, 4 months after inoculation, were abandoned, because in those cases where they became patent later the microfilaria density did not reach an appropriate level. The selected jirds were used for experiment from 6 to 15 months after inoculation when most of them revealed the maximal count of microfilariae. The jirds that failed to develop microfilaremia to the level of 10 mf/microliters by 9 months after inoculation were also abandoned because they did not continue the appropriate level of microfilaremia even when they reached this level later. Although a significant periodicity was observed only in of 10 jirds examined by the Aikat and Das method, the peak hour of microfilaria density was observed in most animals in the afternoon and the time was nearly the same in each animal. Therefore, the blood sampling would be performed preferably in the afternoon.
PubMed: 3379798
Affiliations:
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Le document en format XML
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Longevity and periodicity of microfilaremia.</title><author><name sortKey="Maeda, R" sort="Maeda, R" uniqKey="Maeda R" first="R" last="Maeda">R. Maeda</name><affiliation wicri:level="3"><nlm:affiliation>Department of Parasitology, Teikyo University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Parasitology, Teikyo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Hayashi, Y" sort="Hayashi, Y" uniqKey="Hayashi Y" first="Y" last="Hayashi">Y. Hayashi</name></author><author><name sortKey="Shibuya, T" sort="Shibuya, T" uniqKey="Shibuya T" first="T" last="Shibuya">T. Shibuya</name></author></analytic><series><title level="j">The Japanese journal of experimental medicine</title><idno type="ISSN">0021-5031</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anthelmintics (therapeutic use)</term><term>Arsenicals (therapeutic use)</term><term>Brugia (growth & development)</term><term>Brugia (isolation & purification)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Drug Evaluation, Preclinical (methods)</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Filariasis (drug therapy)</term><term>Filariasis (parasitology)</term><term>Filaricides (therapeutic use)</term><term>Gerbillinae (parasitology)</term><term>Male</term><term>Mebendazole (analogs & derivatives)</term><term>Mebendazole (therapeutic use)</term><term>Microfilariae</term><term>Periodicity</term><term>Suramin (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antihelminthiques (usage thérapeutique)</term><term>Brugia (croissance et développement)</term><term>Brugia (isolement et purification)</term><term>Composés de l'arsenic (usage thérapeutique)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (sang)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (parasitologie)</term><term>Filarioses (traitement médicamenteux)</term><term>Gerbillinae (parasitologie)</term><term>Microfilaria</term><term>Mâle</term><term>Mébendazole (analogues et dérivés)</term><term>Mébendazole (usage thérapeutique)</term><term>Périodicité</term><term>Suramine (usage thérapeutique)</term><term>Évaluation préclinique de médicament ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Mebendazole</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Mébendazole</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Evaluation, Preclinical</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term><term>Gerbillinae</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Gerbillinae</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anthelmintics</term><term>Arsenicals</term><term>Diethylcarbamazine</term><term>Filaricides</term><term>Mebendazole</term><term>Suramin</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihelminthiques</term><term>Composés de l'arsenic</term><term>Diéthylcarbamazine</term><term>Filaricides</term><term>Mébendazole</term><term>Suramine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Microfilariae</term><term>Periodicity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Microfilaria</term><term>Mâle</term><term>Périodicité</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The longevity and periodicity of microfilaremia were examined in the jird infected with Brugia malayi to be used for assessing the filaricides. Jirds 4 to 6 weeks old were inoculated subcutaneously with 100 to 200 infective larvae of B. malayi. Microfilariae were present in 75 out of 94 jirds observed over 3 years and high microfilaremia, with 10 mf/microliters or higher, developed in 43 out of 75 jirds. Such a high level of microfilaremia was necessary for narrowing the variation of microfilaria counts among the blood samples. The microfilaria negative jirds, 4 months after inoculation, were abandoned, because in those cases where they became patent later the microfilaria density did not reach an appropriate level. The selected jirds were used for experiment from 6 to 15 months after inoculation when most of them revealed the maximal count of microfilariae. The jirds that failed to develop microfilaremia to the level of 10 mf/microliters by 9 months after inoculation were also abandoned because they did not continue the appropriate level of microfilaremia even when they reached this level later. Although a significant periodicity was observed only in of 10 jirds examined by the Aikat and Das method, the peak hour of microfilaria density was observed in most animals in the afternoon and the time was nearly the same in each animal. Therefore, the blood sampling would be performed preferably in the afternoon.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hayashi, Y" sort="Hayashi, Y" uniqKey="Hayashi Y" first="Y" last="Hayashi">Y. Hayashi</name><name sortKey="Shibuya, T" sort="Shibuya, T" uniqKey="Shibuya T" first="T" last="Shibuya">T. Shibuya</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Maeda, R" sort="Maeda, R" uniqKey="Maeda R" first="R" last="Maeda">R. Maeda</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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